GETTING MY SIK TO WORK

The functionality of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which performs a very important regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also mark